The pair played boy genius Malcolm's parents Lois and Hal in the hit sitcom from 2000 to 2006, and now they will reteam in a much darker setting for the last run of Cranston's critically acclaimed drama.
Breaking Bad star Dean Norris uploaded a snap of Cranston and Kaczmarek last week (ends27Jan12), sparking speculation the actress had agreed to appear alongside her former TV partner.
Now she has confirmed her casting in a post of Twitter.com, writing, ""Yes, it's true... I will indeed be on Breaking Bad. Can't wait for you all to see it. Congrats (sic) to Bryan Cranston for his win (at the Screen Actors Guild Awards).""
Cranston added to his Breaking Bad trophy haul when he picked up the prize for Outstanding Performance by a Male Actor in a Drama Series at the awards show on Sunday (27Jan13).